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KMID : 0380020090240030321
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Korean Journal of Biotechnology and Bioengineering
2009 Volume.24 No. 3 p.321 ~ p.326
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Optimization of Medium for Astaxanthin Production by Paracoccus sp. Using Response Surface Methodology
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Choi Jong-Il
Lee Hee-Sub
Choi Seon-Kang
Kim Jae-Hun
Kim Jin-Kyu
Byun Myung-Woo
Lee Ju-Woon
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Abstract
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This study was to optimize the medium components for astaxanthin production in Paracoccus sp. through surface response methodology. A screening test was first conducted on 5 medium components using a Plackett-Burman design, from which and yeast extract were identified as the significant factors affecting astaxanthin production. These significant factors were optimized by central composite design of experiments and response surface methodology, as 2.83 g/L and 7.02 g/L yeast extract, respectively. The expected astaxanthin concentration with these optimized medium compositions were 0.925 mg/L. In flask culture, the experimentally obtained concentration of astaxantin was 1.021 mg/L, where it had been 0.4 mg/L before optimization.
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KEYWORD
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Response surface method, astaxanthin, Paracoccus sp.
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